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I aim at the same spot from both a ground blind and tree stand. I aim at the bottom third of the deer just behind the shoulder. I hug the shoulder tight as the primary leg bone is at an angle toward the deer’s head. I’d rather be a touch forward than back.
I don’t take shots with a bow at deer that are strongly quartering toward me. It’s possible to bust through the shoulder, but I believe the animal deserves more respect than to take a risky shot.
My stands are rarely more than 20-22′ high. This allows the arrow trajectory to pass through both lungs.